Publications
46. Katsoulis, I. A.; Kythreoti, G.; Papakyriakou, A.; Koltsida, K.; Anastasopoulou, P.; Stathakis, C. I; Mavridis, I.; Cottin, T.; Saridakis, E.; Vourloumis, D., “Synthesis of 5,6-spiroethers and evaluation of their affinity for the bacterial A-site”, ChemBioChem 2011, 12, 1188-1192
45. E. Zervoudi, A. Papakyriakou, D. Georgiadou, I. Evnouchidou, A. Gajda, M. Poreba, G.S. Salvesen, M. Drag, A. Hattori, L. Swevers, D. Vourloumis, E. Stratikos, “Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides”, Biochem. J. 2011, 435, 411–420
44. Kythreoti, G.; Vourloumis, D., “A Homo sapiens Cytoplasmic Ribosomal Decoding A-site Affinity Screen Evaluating Aminoglycoside- and Analogues-Binding”, Anal. Biochem. 2011, 412, 102-107
43. T. Cottin, C. Pyrkotis, C.I. Stathakis, I. Mavridis, I.A. Katsoulis, P. Anastasopoulou, G. Kythreoti, A.L Zografos, V.R. Nahmias, A. Papakyriakou, D. Vourloumis, “Designed spiro-bicyclic analogues targeting the ribosomal decoding center”, ChemBioChem 2011, 12, 71-87
42. C.I. Stathakis, I. Mavridis, G. Kythreoti, A. Papakyriakou, I.A. Katsoulis, T. Cottin, P. Anastasopoulou, D. Vourloumis, “Second generation analogues of rigid 6,7-spiro scaffolds targeting the bacterial ribosome”, Bioorg. Med. Chem. Lett. 2010, 20, 7488-7492
41. V. P. Androutsopoulos, A. Papakyriakou, D. Vourloumis, A. M. Tsatsakis, D. A. Spandidos, “Dietary flavonoids in cancer therapy and prevention: Substrates and inhibitors of cytochrome P450 CYP1 enzymes”, Pharmacology & Therapeutics 2010, 126, 9-20
40. A. Papakyriakou, M.E. Katsarou, M. Belimezi, M. Karpusas, D. Vourloumis, “Discovery of Potent Vascular Endothelial Growth Factor Receptor-2 Inhibitors Assisted by Computational Methods”, ChemMedChem 2010, 5, 118-129
39. I.A. Katsoulis, C. Pyrkotis, A. Papakyriakou, G. Kythreoti, A.L. Zografos, I. Mavridis, V.R. Nahmias, P. Anastasopoulou and D. Vourloumis, “Unnatural rigid scaffolds targeting the ribosomal RNA” ChemBioChem 2009, 10, 1969-1972
38. A. Papakyriakou, D. Vourloumis, F. Tzortzatou-Stathopoulou, M. Karpusas, “Conformational dynamics of the EGFR kinase domain reveals structural features involved in activation.” Proteins 2009, 76, 375-386
37. E.K. Efthimiadou, M.E. Katsarou, M. Fardis, C. Zikos, E.N. Pitsinos, A. Kazantzis, L. Leondiadis, M. Sagnou, D. Vourloumis, “Synthesis and characterization of novel natural product-Gd(III) MRI contrast agent conjugates.” Bioorg. Med. Chem. Lett. 2008, 18, 6058-6061
36. M.E. Katsarou, Ε.Κ. Efthimiadou, G. Psomas, A. Karaliota, D. Vourloumis, “Novel Copper(II) Complex of N-Propyl-norfloxacin and 1,10-Phenanthroline with Enhanced Antileukemic and DNA Nuclease Activities”, J. Med. Chem. 2008, 51, 470-478
35. Y. Zhou, V.E. Gregor, Z. Suyn, B.K. Ayida, G.C. Winters, D. Murphy, K.B. Simonsen, D. Vourloumis, S. Fish, J.M. Froelich, D. Wall, T. Hermann, “Structure-guided discovery of novel aminoglycoside mimetics as antibacterial translation inhibitors.” Antimicrob. Agents Chemother. 2005, 49, 4942–4949
34. B. Ayida, K.B. Simonsen, D. Vourloumis, T. Hermann, “Synthesis of dehydroalanine fragments as thiostrepton side chain mimetics.” Bioorg. Med. Chem. Lett. 2005, 15, 2457–2460
33. Q. Han, Q. Zhao, S. Shandrick, K.B. Simonsen, D. Vourloumis, J.M. Froelich, D. Wall, T. Hermann, “Molecular Recognition by Glycoside Pseudo Base Pairs and Triples in an Apramycin-RNA Complex.” Angew. Chem. Int. Ed. 2005, 44, 2694–2700
32. D. Vourloumis, G.C. Winters, K.B. Simonsen, M. Takahashi, B. Ayida, S. Shandrick, Q. Zhao, Q. Han, T. Hermann, “Aminoglycoside-Hybrid Ligands Targeting the Ribosomal Decoding Site.” ChemBioChem 2005, 6, 58–65
31. S. Shandrick, Q. Zhao, Q. Han, B. Ayida, M. Takahashi, G.C. Winters, K.B. Simonsen, D. Vourloumis, T. Hermann, “Monitoring Molecular Recognition of the Ribosomal Decoding Site.” Angew. Chem. Int. Ed. 2004, 43, 3177–3182
30. K.C. Nicolaou, Y. Li, K. Sugita, H. Monenschein, P. Guntupalli, H.J. Mitchell, K.C. Fylaktakidou, D. Vourloumis, P. Giannakakou, A. O’Brate, “Total Synthesis of Apoptolidin: Completion of the Synthesis and Analogue Synthesis and Evaluation.” J. Am. Chem. Soc. 2003, 125, 15443–15454
29. S. Barluenga, K.B. Simonsen, E. Littlefield, B. Ayida, D. Vourloumis, G.C. Winters, M. Takahashi, S. Shandrick, Q. Zhao, Q. Han, T. Hermann, “Rational Design of Azepane-Glycoside Antibiotics Targeting the Bacterial Ribosome.” Bioorg. Med. Chem. Lett. 2004, 14, 713–718
28. K.B. Simonsen, B. Ayida, D. Vourloumis, G.C. Winters, M. Takahashi, S. Shandrick, Q. Zhao, T. Hermann, “Piperidine Glycosides Targeting the Ribosomal Decoding Site.” ChemBioChem 2003, 4, 886–890
27. D. Vourloumis, G.C. Winters, M. Takahashi, K.B. Simonsen, B. Ayida, S. Shandrick, Q. Zhao, T. Hermann, “ Novel Acyclic Deoxystreptamine Mimetics Targeting the Ribosomal Decoding Site.” ChemBioChem 2003, 4, 879–885
26. D. Vourloumis, M. Takahashi, K.B. Simonsen, B. Ayida, S. Barluenga, G.C. Winters, T. Hermann, “Solid phase synthesis of benzimidazole libraries biased for RNA-targets.” Tetrahedron Lett. 2003, 44, 2807–2811
25. D. Vourloumis, M. Takahashi, G.C. Winters, K.B. Simonsen, B. Ayida, S. Barluenga, S. Qamar, S. Shandrick, Q. Zhao, T. Hermann, “ Novel 2,5-Dideoxystreptamine Derivatives Targeting the Ribosomal Decoding Site RNA.” Bioorg. Med. Chem. Lett. 2002, 12, 3367–3372
24. K.B. Simonsen, B. Ayida, D. Vourloumis, M. Takahashi, G.C. Winters, S. Barluenga, S. Qamar, S. Shandrick, Q. Zhao, T. Hermann, “ Novel Paromamine Derivatives Exploring Shallow Groove Recognition of Ribosomal Decoding Site RNA.” ChemBioChem 2002, 3, 1223–1228
23. R.A. Newman, J. Yang, M.R.V. Finlay, F. Cabral, D. Vourloumis, C. Stevens, P. Troncoso, X. Wu, C.J. Logothetis, K.C. Nicolaou, N.M. Navone, “Antitumor Efficacy of 26-Fluoroepothilone B Against Human Prostate Cancer Xenografts.” Cancer Chemother. Pharmacol. 2001, 48, 319–326
22. K.C. Nicolaou, D. Vourloumis, N. Winssinger, P.S. Baran, "The Art and Science of Total Synthesis at the Dawn of the Twenty-First Century." Angew. Chem. Int. Ed. 2000, 39, 44–122 [cover]
21. K.C. Nicolaou, J. Pfefferkorn, J. Xu, N. Winssinger, T. Ohshima, S. Kim, S. Hosokawa, D. Vourloumis, F. Van Delft, T. Li, "Total Synthesis and Chemical Biology of the Sarcodictyins." Chem. Pharm. Bull. 1999, 47, 1199–1213.
20. E. Hamel, D.L. Sackett, D. Vourloumis, K.C. Nicolaou, "The Coral-Derived Natural Products Eleutherobin and Sarcodictyins A and B: Effects on the Assembly of Purified Tubulin with and without Microtubule-Associated Proteins and Binding at the Polymer Taxoid Site." Biochemistry 1999, 38, 5490–5498
19. K.C. Nicolaou, N. Winssinger, D. Vourloumis, T. Ohshima, S. Kim, J. Pfefferkorn, J.-Y. Xu, T. Li, "Solid and Solution Phase Synthesis and Biological Evaluation of Combinatorial Sarcodictyin Libraries." J. Am. Chem. Soc. 1998, 120, 10814–10826
18. K.C. Nicolaou, T. Ohshima, S. Hosokawa, F. van Delft, D. Vourloumis, J.-Y. Xu, J. Pfefferkorn, S. Kim, "Total Synthesis of Eleutherobin and Eleuthosides A and B." J. Am. Chem. Soc. 1998, 120, 8674–8680
17. K.C. Nicolaou, J.-Y. Xu, J. Pfefferkorn, T. Ohshima, D. Vourloumis, S. Hosokawa, "Total Synthesis of Sarcodictyins A and B." J. Am. Chem. Soc. 1998, 120, 8661–8673
16. K.C. Nicolaou, N.P. King, M.R.V. Finlay, Y. He, F. Roschangar, D. Vourloumis, H. Vallberg, F. Sarabia, S. Ninkovic, D. Hepworth, "Total Synthesis of Epothilone E and Related Side Chain Modified Analogues via a Stille Coupling Based Strategy." Bioorg. Med. Chem. 1999, 7, 665–697
15. K.C. Nicolaou, M.R.V. Finlay, S. Ninkovic, N.P. King, Y. He, T. Li, F. Sarabia, D. Vourloumis, "Synthesis and Biological Properties of C12,13-Cyclopropyl-Epothilone A and Related Epothilones." Chem. & Biol. 1998, 5, 365–372
14. K.C. Nicolaou, S. Kim, J. Pfefferkorn, J.-Y. Xu, T. Ohshima, S. Hosokawa, D. Vourloumis, T. Li, "Chemical Synthesis and Biology of Sarcodictyins." Angew. Chem. Int. Ed. 1998, 37, 1418–1421
13. K.C. Nicolaou, F. Roschangar, D. Vourloumis, "Chemical Biology of Epothilones." Angew. Chem. Int. Ed. 1998, 37, 2014–2045 [cover]
12. K.C. Nicolaou, F. van Delft, T. Ohshima, D. Vourloumis, J. Xu, S. Hosokawa, J. Pfefferkorn, S. Kim, T. Li, "Total Synthesis of Eleutherobin." Angew. Chem. Int. Ed. Engl. 1997, 36, 2520–2524
11. K.C. Nicolaou, Y. He, F. Roschangar, N.P. King, D. Vourloumis, T. Li, "Total Synthesis of Epothilone E and Analogues with Modified Side Chains through the Stille Coupling Reaction." Angew. Chem. Int. Ed. 1998, 37, 84–87
10. K.C. Nicolaou, D. Vourloumis, T. Li, J. Pastor, N. Winssinger, Y. He, S. Ninkovic, F. Sarabia, H. Vallberg, F. Roschangar, N.P. King, M.R.V. Finlay, P. Giannakakou, P. Verdier-Pinard, E. Hamel, "Designed Epothilones: Solid Phase Synthesis on Microtubes, Tubulin Assembly Properties and Cytotoxic Action Against Taxol-Resistant Tumor Cells." Angew. Chem. Int. Ed. Engl. 1997, 36, 2097–2103
9. K.C. Nicolaou, F. Sarabia, M.R.V. Finlay, S. Ninkovic, N.P. King, D. Vourloumis, Y. He, “Total Synthesis of Oxazole- and Cyclopropane-Containing Epothilone B Analogues by the Macrolactonization Approach." Chem. Eur. J. 1997, 3, 1971–1986
8. K.C. Nicolaou, H. Vallberg, N.P. King, F. Roschangar, Y. He, D. Vourloumis, C.G. Nicolaou, "Total Synthesis of Oxazole- and Cyclopropane-Containing Epothilone A Analogues by the Olefin Metathesis Approach." Chem. Eur. J. 1997, 3, 1957–1970
7. K.C. Nicolaou, S. Ninkovic, F. Sarabia, D. Vourloumis, Y.He, H. Vallberg, Z. Yang, "Total Synthesis of Epothilones A and B via a Macrolactonization Based Strategy." J. Am. Chem. Soc. 1997, 119, 7974–7991
6. K.C. Nicolaou, Y. He, D. Vourloumis, H. Vallberg, F. Roschangar, F. Sarabia, S. Ninkovic, Z. Yang, J.I. Trujillo, "The Olefin Metathesis Approach to Epothilone A and Its Analogs." J. Am. Chem. Soc. 1997, 119, 7960–7973
5. K.C. Nicolaou, N. Winssinger, J. Pastor, S. Ninkovic, F. Sarabia, Y. He, D. Vourloumis, Z. Yang, T. Li, P. Giannakakou, E. Hamel, "Synthesis of Epothilones A and B in Solid and Solution Phase." Nature 1997, 387, 268–272
4. Z. Yang, Y. He, D. Vourloumis, H. Vallberg, K.C. Nicolaou,"Total Synthesis of Epothilone A: The Olefin Metathesis Approach." Angew. Chem. Int. Ed. Engl. 1997, 36, 166–168
3. K.C. Nicolaou, Y. He, D. Vourloumis, H. Vallberg, Z. Yang, "An Approach to Epothilones Based on Olefin Metathesis." Angew. Chem. Int. Ed. Engl. 1996, 35, 2399–2401
2. D. Vourloumis, K.D. Kim, J.L. Petersen, P.A. Magriotis, "Cobalt-Assisted Claisen Rearrangement of Enediyne Lactones at Ambient Temperature. Studies toward a Synthetic Application of the Myers Cycloaromatization." J. Org. Chem. 1996, 61, 4848–4852
1. P.A. Magriotis, D. Vourloumis, M.E. Scott, A. Tarli, "Novel Generation of Conjugated Alkynyl Ketenes. Efficient Synthesis of b,g-Alkynyl Lactones." Tetrahedron Lett. 1993, 34, 2071–2074
